Pathophysiology and Treatment of Meningitis and Encephalitis
Pathophysiology and Treatment of Meningitis and Encephalitis
Description of the Diseases
Meningitis is an inflammation of the meninges, the tissue surrounding the brain and spinal cord. There are five types of meningitis: bacterial, viral, fungal, parasitic or non-infectious in origin. The most prevalent type being is viral (Centers for Disease Control and Prevention [CDC], 2014). The incidence of bacterial meningitis is about 1.3 in 100,000 whereas the estimated incidence of viral meningitis is about 11 in 100,000 (2014; Wan, 2013).
The first type of meningitis is bacterial. The two most prevalent organisms found are meningococcus and pneumococcus. Both are considered communicable. Meningococcal meningitis tends to affect males from the fall to spring season with epidemics in young children and adolescents which generally occur every 10 years. Pneumonoccal meningitis tends to be found in the young and those older than 40 years with these three predisposing conditions: sinusitis, a weak immune systems and pneumonia (Huether & McCance, 2012).
The second type of meningitis is viral. In the United States, non-polio enteroviruses are the most prevalent causative pathogens. Those most at risk are children less than 5 years old and the immunocompromised with the highest incidence during the summer and fall seasons. Herpesviruses, measles, mumps, influenza and arboviruses are also identified pathogens. Viral meningitis is considered contagious (CDC, 2014).
The third type of meningitis is fungal. It is usually found in immunocompromised persons infected with Cryptococcus and is not considered contagious (CDC, 2014). The disease also “develops insidiously” compared to bacterial and viral meningitis, both of which have rapid onset (2014; Huether & McCance, 2012, p. 394). However, it is “one of the most common causes of adult meningitis in Africa” (CDC, 2014).
The fourth type of meningitis is parasitic. It is usually caused by Naegleria fowleri, a microscopic ameba found in warm freshwater. The organism gains access to the brain through the nose and causes parasitic meningitis, a fatal but rare infection with only 31 reported cases from 2003 to 2012 (CDC, 2014). It is not contagious.
Lastly, noninfectious meningitis is associated with cancer, Lupus, certain drugs, neurosurgeries and traumatic brain injuries and is beyond the scope of this paper (Huether & McCance, 2014).
Encephalitis is characterized by inflammation of the brain and febrile illness similar to meningitis, but differs in that it presents with associated CNS involvement. It is usually viral in origin. Incidence is estimated at 20,000 per year in the United States (Whitley, 1990). The most common infectious viral agents are herpes simplex type 1 and arboviruses. A well-known arbovirus in Southern California is West Nile Virus. Post infectious encephalitis is a complication of a systemic viral infection, mainly poliomyelitis, rabies, mononucleosis or recovery from measles. It can also occur secondary to live attenuated MMR vaccinations (Huether & McCance, 2012).
Pathological Mechanisms Bacterial meningitis usually begins as a systemic infection, bacteremia or direct invasion from an infected area, such as the sinuses. The organisms invade the subarachnoid space and initiate an acute inflammatory process with neutrophil migration. The inflammation is compounded by bacterial toxins and cytotoxic agents which damage brain cells and increase vessel permeability. Increased intracranial pressure occurs due to the combination of swollen meningeal cells and bacterial exudate. Hydrocephalus occurs if excessive exudates block the arachnoid villi (Huether & McCance, 2012).
Fungal meningitis also invades the CNS via the bloodstream. However, it causes a granulomatous reaction in addition to inflammation. Formation of gelatinous masses and fibrosis damages cranial
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Neisseria meningitis Kingdom-Bacteria Phylum-Proteobacteria Class-Beta Proteobacteria Order-Neisseriales Family-Neisseriaceae Genus-Neisseria Species-N. meningitis Neisseria meningitides is a gram negative, diplococci, aerobic, pathogenic organism. This organism is the common cause of bacterial meningitis in young children and adults alike. Meningitis is an inflammation of the meninges, which are the protective membranes covering the brain and the spinal cord. Because inflammation in this…
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Meningitis: North America v. Sub Saharan Africa Meningitis is a horrible bacterial or viral infection of the central nervous system. The sheer level of damage this infection can cause is enough to send fear down the bravest spine. However, as terrible as this infection is at home, in North America, I wanted to research and compare how well or poorly controlled this infection is in a less developed country, Sub Saharan Africa. My essay will include the causative agent and symptoms of meningitis…
All our staff even temporary, staff supply and volunteers understand their responsibilities and have had the appropriate training and know how to support this role. They understand their responsibilities in being alert to the signs of abuse and referring any concerns to Mr D Knill who is the deputy protection officer who will record the date, the time and the verbatim report given by the format. We also have a governor co-ordinator as well who is Mrs Leaver she is also a teaching assistant which…
conjunctiva of the eye. The conjunctiva is the membrane that lines the inside of the eyelid and also a thin membrane that covers the actual eye. Sinusitis. Infection in the sinuses. Meningitis. Due to the H. influenzae type b vaccine, meningitis (due to this bacteria) is very rare in children and infants. Meningitis is an infection of the membranes that surround the brain and spinal cord. Symptoms may include: In children older than 1 year: Neck and/or back pain, especially when moving the chin toward…
the brain causing serious illness. There can be two different forms of meningococcal depending on which part of the body the bacteria invade. There can be Meningitis or Septicaemia, or a combination of both. Meningitis is caused by an inflammation of the lining of the brain and spinal cord. There are many different forms of Meningitis, however it is only the more serious bacterial form that causes meningococcal. Septicaemia is the more dangerous of the two forms and occurs when bacteria enters…
Meningitis – Heartwarming Story of a Real Survivor Shalinie Bandaranayaka REHB 110W Instructor: Connie Giles Minnesota State University, Mankato Meningitis – Heartwarming Story of a Real Survivor I saw him last month in Burnsville when I went to help one of my friends to move her furniture to a different house in Shakopee. I realized that he looked like someone from Srilanka, which is my home country. The fact that his car was parked in the accessible parking space took me by surprise…
Childhood illnesses Most children and young people will experience some illness in their life. Common illnesses like coughs and cold are not usually serious. However, illnesses like meningitis are more serious and the child will need specialist medical care. Illnesses like chicken pox are infectious to others and illnesses like asthma are not infectious at all. The main signs that a child is ill are: Poor appetite. No energy. Change in behaviour (unusually quiet, not sleeping well, crying more…