organisms (e.g., lipoteichoic acid, peptidoglycan), as well as fungal, viral, and parasitic components. Signaling by these mediators occurs via a family of transmembrane receptors known as Toll-like receptors. Within the monocyte, nuclear factor-κB (NF-κB), is activated, which leads to the production of pro-inflammatory cytokines, tumor necrosis factor α, and interleukin 1. TNF-α and IL-1 lead to the production of toxic downstream mediators, including prostaglandins, leukotrienes, platelet-activating…
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