Daniel Albrecht 9/11/14 Dr. Chambers Lab 499Y proposal Synthesis of a Click Chemistry Small Molecule Tracking Agent for GluA2 Unedited Receptors in ALS 1. The currently incurable neurodegenerative disease ALS causes excitotoxic cell death in motor neurons, leading to difficulty moving, speaking, swallowing, and breathing. Patients typically live just 3-5 years after the initial presentation of symptoms, with little recourse.1 The only available medication, Riluzole, affords only a fraction of…
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