A Review On Illumina

Submitted By Shanealc73
Words: 2256
Pages: 10

With Non-Invasive Down Syndrome Test, Illumina Sees Market in Sequencing the DNA of Fetuses | MIT Technology Review

3/2/14 10:58 AM

"#$%&'&()*+,)-$./$%01%2
3$&41%2)'5$)*+,)67)7$'/8$8)18)'5$)%$9')7#6%'1$#)67)'5$)2$%6:$
#$;6(/'16%<)*6)=6/)#$&((=)>&%')'6)?%6>)'5$)2$%$'10)4$8'1%=)67)=6/#
/%@6#%)051(4A
!"#$%&'%('#)*+,-,.'#'%#$/0(-#123#1452

!

,0-(*0#&6(7#"*,0#8--9:(%,3#&6*#:,;*0#'<#&6*#='0-.>7#:'7&#=(.*-"#97*.#?@$#7*A9*%B(%+#:,B6(%*73
,+0**.#&'#/,"#%*,0-"#6,-<#,#C(--('%#.'--,07#<'0#D*0(%,&,3#,#7&,0&9/#(%#)*.=''.#E(&"3#E,-(<'0%(,3#&6,,7
6,0.-"#,%"#0*F*%9*7G#H6,&#D*0(%,&,#.'*7#6,F*#(7#&*B6%'-'+"#&6,&#B,%#.'#7':*&6(%+#,7#*&6(B,--"#<0,9+6&
,7#(&#(7#(%*F(&,C-*I#7*A9*%B*#&6*#?@$#'<#,#69:,%#<*&97#C*<'0*#C(0&6G
D*0(%,&,#(7#'%*#'<#<'90#JGKG#B':/,%(*7#,-0*,."#(%F'-F*.#(%#,#0,/(.-"#*L/,%.(%+#:,0;*&#<'0#/0*%,&,-#?@$
&*7&(%+#97(%+#8--9:(%,>7#7*A9*%B*07G#M6*(0#*L(7&(%+#&*7&73#,--#-,9%B6*.#(%#&6*#-,7N#:'%&673#B,%#.*&*B&
?'=%#7"%.0':*#<0':#&0,B*7#'<#<*&,-#?@$#<'9%.#(%#,#7"0(%+*<9-#'<#&6*#:'&6*0>7#C-''.G#J%&(-#%'=3
.*&*B&(%+#?'=%#7"%.0':*#6,7#:*,%&#+0,CC(%+#<*&,-#B*--7#<0':#&6*#/-,B*%&,#'0#&6*#,:%('&(B#<-9(.3
/0'B*.90*7#&6,&#B,00"#,#7:,--#0(7;#'<#:(7B,00(,+*G
M6*#%'%(%F,7(F*#7B0**%#(7#7'#:9B6#7,<*0#,%.#*,7(*0#&6,&#(&>7#C*B':*#'%*#'<#&6*#:'7&#A9(B;-"#,.'/&*.
&*7&7#*F*0#,%.#,%#(:/'0&,%&#%*=#:*.(B,-#,//-(B,&('%#<'0#8--9:(%,>7#?@$#7*A9*%B(%+#(%7&09:*%&73#=6(B6
6,F*#7'#<,0#C**%#97*.#:,(%-"#(%#0*7*,0B6#-,C7G#8%#O,%9,0"3#8--9:(%,>7#EPQ3#O,"#R-,&-*"3#&'-.#(%F*7&'07#&6,&
6*#*L/*B&7#&6*#&*7&7#=(--#*F*%&9,--"#C*#'<<*0*.#&'#,7#:,%"#,7#&='#:(--('%#=':*%#,#"*,0#(%#&6*#J%(&*.
K&,&*73#0*/0*7*%&(%+#6,-<#'<#,--#/0*+%,%B(*7S9/#<0':#,0'9%.#1T43444#:'&6*073#:'7&-"#'-.*03#=6'#%'=
9%.*0+'#&6*#(%F,7(F*#&*7&7G#U8&>7#9%/0*B*.*%&*.#(%#:*.(B,-#&*7&(%+#6'=#<,7&#&6(7#6,7#+'%*#<0':#-,C http://www.technologyreview.com/featuredstory/513691/prenatal-dna-sequencing/ Page 1 of 6

With Non-Invasive Down Syndrome Test, Illumina Sees Market in Sequencing the DNA of Fetuses | MIT Technology Review

3/2/14 10:58 AM

0*7*,0B6#&'#,BB*/&,%B*3V#7,"7#?(,%,#!(,%B6(3#*L*B9&(F*#.(0*B&'0#'<#&6*#W'&6*0#8%<,%&#)*7*,0B6#8%7&(&9&*
,&#M9<&7#J%(F*07(&"#,%.#&6*#B6(*<#B-(%(B,-#,.F(7'0#&'#D*0(%,&,G#U8&>7#,#69+*#(:/,B&#<'0#,%"#&*B6%'-'+"#(%#(&7
<(07&#"*,0GV
!9&#&6(7#(7#-(;*-"#&'#C*#X97&#&6*#7&,0&#<'0#/0*%,&,-#?@$#7*A9*%B(%+G#M6*#7,:*#-,C7#,%.#B':/,%(*7#&6,&
-,9%B6*.#&6*#?'=%#7"%.0':*#&*7&73#-(;*#D*0(%,&,3#6,F*#,-7'#<(+90*.#'9'=#&6*"#B,%#+*&#:9B6#:'0*
(%<'0:,&('%#<0':#,#:'&6*0>7#C-''.7&0*,:3#(%B-9.(%+#&6*#B':/-*&*#+*%':*#7*A9*%B*#'<#6*0#<*&97G#M6,&>7
,#&*B6%(B,-#C0*,;&60'9+63#,%.#:,"C*#,#B'::*0B(,-#'%*3#&''G#Y0*+%,%B"3#=(&6#(&7#6'/*73#,%L(*&(*73#,%.
<0*A9*%&#.'B&'0>7#F(7(&73#B'9-.#C*#=6*0*#+*%':*#7*A9*%B(%+#<(%,--"#<(%.7#,#:,X'0#B'%79:*0#,//-(B,&('%G
U8#&6(%;#&6,&#=*#,0*#+'(%+#&'#7*A9*%B*#&6*#+*%':*#'<#*F*0"'%*S'<#*F*0"#<*&97S#(%#&6*#<(07&#&0(:*7&*03#,&
-*,7&#(%#/,0&3V#7,"7#$0&690#!*,9.*&3#,#/*.(,&0(B(,%#,%.#6*,.#'<#69:,%#+*%*&(B7#,&#&6*#!,"-'0#E'--*+*#'<
W*.(B(%*3#(%#Z'97&'%G#M'.,"#7':*#/,&(*%&7#6,F*#&6*(0#+*%':*7#7*A9*%B*.#&'#76*.#-(+6&#'%#+*%*&(B
.(7*,7*7#'0#(--%*77*7#-(;*#B,%B*03#C9&#'%*#.,"#/*'/-*#='%>&#=,( %&(-#&6*">0*#7(B;G#UH*#,0*#,-0*,."#+'(%+
&'#;%'=#&6*#.,&,#,&#C(0&63V#6*#7,"7G
M6,&#='%>,//*%#0(+6&#,=,"G#R'0#'%*#&6(%+3#7'0&(%+#'9&#,#<*&97>7#*L,B&#?@$#B'.*#F(,#(&7#:'&6*0>7#C-''.
0*A9(0*7#,#69+*#,:'9%&#'<#0*/*,&*.#7*A9*%B(%+3#:,;(%+#(&#&''#*L/*%7(F*#<'0#0'9&(%*#97*G#[8--9:(%,
B900*%&-"#B6,0+*7#\]3T44#&'#7*A9*%B*#&6*#+*%':*#'<#,%#,.9-&3#,%.#7'#<,0#,&&*:/&7#&'#7*A9*%B*#<*&,?@$#6,F*#B'7&#:9B6#:'0*G^#$%.#&6*0*#,0*#7&(--#&*B6%(B,-#/0'C-*:7I#&6*#<*&,-#+*%':*#0*79-&7#,0*#7&(--#%'&
,BB90,&*#*%'9+6#<'0#:,;(%+#.(,+%'7*7G#P&6(B,--"3#&''3#&6*#&*B6%'-'+"#(7#,#:(%*<(*-.G#8<#=*#-*,0%#&6*
+*%*&(B#.*7&(%"#'<#'90#B6(-.0*%#=6(-*#&6*"#,0*#7&(--#(%#&6*#=':C3#=6,&#;(%.7#'<#B6'(B*7#:(+6&#=*#:,;*_
UM*B6%(B,--"3#,--#&6(7#(7#/'77(C-*#C*<'0*#=*>F*#<(+90*.#'9&#=6*&6*0#=*#76'9-.#C*#.'(%+#(&3V#7,"7#O,"
K6*%.90*3#,#+*%':*#7B(*%&(7&#,&#&6*#J%(F*07(&"#'<#H,76(%+&'%G#U`'9>F*#+'&#&6*#=6'-*#+*%':*S&6*%