bacterial, chemical, thermal or mechanical injury. It is a global issue, which is a serious threat to animal health, also reduces the quantity and quality of milk (Patnaik et al., 2013) and is responsible for more than $2 billion annual losses to the US dairy industry (Sordillo LM, Streicher KL, 2002). It is regarded as a serious disease that causes reduced milk quality and animal welfare, extensive losses due to production loss, increased treatment costs and labor, and higher culling rates (Halasa…
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