these studies include biochemical markers of bone resorption and formation, histomorphometric analysis of bone architecture, measurement of bone density and biomechanical testing of bone strength. Histomorphometric, densitometric and biomechanical analyses should be performed on both long bones (femur and tibia) and lumbar vertebral bodies. Whenever possible, the parameters and techniques that will be used to demonstrate clinical efficacy should also be pursued in the preclinical studies. Further recommendations…
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