Greenville SC, Area Analysis Location Greenville is located in the northwestern part of South Carolina. Greenville and the surrounding areas, situated just east of the Blue Ridge Mountains, are frequently referred to as Upstate. The Upstate region includes Greenville, Spartanburg, Anderson, Pickens and Cherokee counties and the cities of Anderson, Clemson, Greenville, Simpsonville, Greer and Spartanburg. * The region is easily accessible from Highways 85, 185, and 385, and U.S. Highways…
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