heavy smoking [9]. Diabesity along the entire continuum of metabolic dysfunction is the primary driver of diabetes, cardiovascular disease [10], stroke, dementia [11], cancer [12], and most chronic disease mortality [13]. A recent 40-year prospective study of 4857 Pima Indian children found that the major predictor of premature death was insulin resistance, not hypertension or hyperlipidemia. Pima Indians in the highest quartile of glucose intolerance had a 73% increase in early death rate compared to…
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