Chapter 1: Introduction to Pharmacology: Drug Regulation and Approval
1. History of Pharmacology
• History likely began when humans first used plants to relieve symptoms of disease.
• Oldest form of health care –Herbal medicine- has been practiced in virtually ever culture back until antiquity
• Modern pharmacology is though to have begun in the early 1800s when scientist began to isolate active agents morphine, colchicine, curare, cocaine, and other natural products.
• They would study their effects in animals, some early researches even used themselves as test subjects.
• Frederich Serturner who first isolated morphine from opium 1805 injected himself with three friends
• First department of pharmacology was established in Estonia in 1847
• John Jacob Abel Father of American Pharmacology founded the first pharmacology department in US at University of Michigan in 1890
• Now became possible to understand how drugs produced their effect
• Early roots: the application of products to relieve human suffering
2. Pharmacology: The study of Medicines
• Pharmacology- Greek “medicine” “study” ranging from the understanding how drugs are administered, where they travel in the body, and actual response produced.
• More than 10000 brand name drugs, generic drugs, combination are currently available
• Drugs may elicit different responses depending on age, sex, body mass, health status, and genetics.
• Learning the application of existing medicating and staying up with current new drugs is an enormous challenge
• If applied properly drugs can dramatically improve quality of life
• If applied improperly drugs can produce devastating consequences
3. Pharmacology and Therapeutics
• Nurses are most often the health care providers directly involved with patient care and are active in educating, managing, and monitoring the proper use of drugs
• Therapeutics-branch of medicine concerned with the prevention of disease and treatment of suffering
• Pharmacotherapy is the application of drugs for the purpose of disease prevention and the treatment of suffering
4. Classification of Therapeutic Agents as Drugs, Biologics, and Alternative Therapies
• Drug- is a chemical agent capable of producing biological responses within the body. Desirable (therapeutic) or undesirable (adverse)
• After a drug is administered it is called medication
• Biologics are agents naturally produced in animal cells, microorganism, or by body itself. Ex. Hormones, monoclonal antibodies, natural blood products, and components, interferon, and vaccines
• Complementary and alternative therapies involve natural plant extract, herbs, vitamins, minerals, dietary supplements, acupuncture, hypnosis, biofeedback, and massage
5. Prescription and Over the Counter Drugs
• To obtain prescription drugs the person must receive a written order from a person with the legal authority to write such a prescription
• OTC drugs do not require a physicians order. Patients prefer OTC because not require physicians order, obtained more easily, no appointment with physician needed, save time and money
6. Drug Regulations and Standards
• First standard commonly used by pharmacist was formulary- list of drugs and drug recipes
• Pharmacopoeia-medical reference summarizing standards of drug purities, strengths, and direction for synthesis
• Pure Food and Drug Act of 1906 gave government power to control the labeling of medicines
• 1938 Food, Drug, and Cosmetic Act first law preventing the sale of drugs that had not thoroughly tested before marketing
7. The Role of the Food and Drug Administration
• Center for Drug evaluation and Research control over whether prescription drugs and OTC drugs me be used for therapy
8. Stages of Approval fro therapeutic and Biologic Drugs
• Preclinical investigation -involves extensive laboratory research- test on humans, animals to examine drug effeteness at different does
• Clinical investigation –longest part of drug
Related Documents: Pharm: Pharmacology and Drug Essay
Chemistry and Structure Activity Relationships for Tetrahydrocannabinols and Endocannabinoids R. K. Razdan Abstract A C op yr ig ht n overview is presented of the chemistry and the known structure activity relationships (SAR) for tetrahydrocannabinols (THCs), endocannabinoids and pyrazole based an tagonists. An attempt has been made to highlight and put in perspective the cannabinoid work carried out before and after the discovery of the receptors. In the cannabinoid…