Background In the period between 1920-1935 Nageotte (1927a, b, 1928, 1930, 1933), Nageotte & Guyon (1933), Leplat (1933), and Faure-Fremiet (1933) had studied and observed the partial dissolution of collagen in dilute solutions of weak acids such as formic and acetic acid. Renewed interest in this soluble protein was generated in the period between 1940-1955 with the works of Orekhovich and his colleagues in the U.S.S.R., who reported the extraction of a soluble collagenous-type protein from the skin…
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