DRUG: cefazolin / (Ancef) Therapeutic Class: anti-infectives
Route:

Dose ordered: Safe dose? Y N
Scheduled, PRN, other: Frequency: Last dose given (date & time):
(if scheduled, indicate time)
INDICATION (why is your pt. taking this?)
Special assessment data?
Perioperative prophylaxis.
Action of drug (physiology)
Binds to bacterial cell wall membrane, causing cell death.
Pharmacokinetics: (absorption, protein binding, metabolism, excretion, half life, route onset peak duration).
Absorption: IM - Well absorbed. Protein Binding: 74—86%. Metab. & Excret: Excreted almost entirely unchanged by the kidneys. / Half-life: 90–150 min (↑ in renal impairment). Route: IV: - Onset: Rapid / Peak: 5 min / Duration: 6–12 hr Route: IM: - Onset: Rapid / Peak: 0.5–2 hr / Duration: 6–12 hr
Contraindications/ Precautions

Contraindicated in: Hypersensitivity to cephalosporins. Serious hypersensitivity to penicillins. Use Cautiously in: Renal impairment. Hepatic impairment. History of GI disease, especially colitis. Geri: Dose adjustment due to age-related ↓ in renal function may be necessary.
Adverse Effects
CNS: SEIZURES (HIGH DOSES). GI: PSEUDOMEMBRANOUS COLITIS, diarrhea, nausea, vomiting, cramps. Derm: STEVENS-JOHNSON SYNDROME, rash, pruritis, urticaria. Hemat: leukopenia, neutropenia, thrombocytopenia. Local: pain at IM site, phlebitis at IV site. Misc: allergic reactions including anaphylaxis and serum sickness, superinfection.
Interactions (drug-drug, drug-natural)
Drug-Drug: Probenecid ↓ excretion and ↑ blood levels of renally excreted cephalosporins.
Nursing Interventions:

Assessment: Assess for infection at beginning of and throughout therapy. Before initiating therapy, obtain a history to determine previous use of and reactions to penicillins or cephalosporins. Persons with a negative history of penicillin sensitivity may