A Case of IPT 1. How and where are platelets produced in the body?
Platelets are produced in the bone marrow, the same as the red cells and most of the white blood cells. Platelets are produced from very large bone marrow cells called megakaryocytes. As megakaryocytes develop into giant cells, they undergo a process of fragmentation that results in the release of over 1,000 platelets per megakaryocyte. The dominant hormone controlling megakaryocyte development is thrombopoietin 2. Describe the role played by platelets in hemostasis.
Platelets contribute to the hemostatic process in two different ways. First, through their adhesive and cohesive functions that leads to the formation of a hemostatic plug. Second, they can activate coagulation mechanisms through the exposure of an adequate phospholipidic surface, acting as a catalytic site for the development of coagulation and the consolidation of the hemostatic plug. 3. Define thrombocytopenia and list the more common causes of this condition.
Blood disorder characterized by an abnormally low number of circulating platelets (thrombocytes) in the bloodstream
Decreased production of platelets by the bone marrow Increased destruction of circulating platelets Increased trapping of platelets by the spleen Platelet loss from hemorrhage 4. What are the potential consequences of a low platelet count?
Your blood would not clot as well in the event of an injury, meaning you could bleed to death without medical