VM PMI-126 1ST MIDTERM

Mark this exam with your answer and take it with you. You can use it to check the key we will post on CERE and establish your successes and failures. The scantrons will not be returned.

1. A hematopoietic stem cell precursor gives rise to both myeloid and lymphoid precursors. Which of the following cells are derived from the myeloid precursor?
a. Neutrophils
b. Eosinophils
c. Granulocytes
d. Polymorphonuclear leukocytes (PMNs)
e. All of the above

2. Would it be logical to reconstitute a patient’s immune system (patient was lethally irradiated to remove all cells of the immune system) using purified hematopoietic stem cells?
a. Yes
b. No

3. A body generates in the vicinity of 1011 white blood cells (WBCs) every day. This requires we eliminate about the same number of WBC’s each day to maintain homeostasis. How are these cells eliminated?
a. Natural killer cells do the elimination
b. WBC’s naturally undergo apoptosis
c. WBC’s naturally undergo necrosis
d. WBC’s return to the bone marrow for rest and then re-enter the blood vasculature at a later time.
e. None of the above

4. Which of the following cells would you expect to leave the blood, enter a tissue and mature into a macrophage?
a. Megakaryocyte/erythrocyte progenitor
b. Lymphoid precursor
c. Stem cell
d. Monocyte
e. None of the above

5. Which of the following white blood cells is most abundant in blood of healthy humans?
a. Lymphocytes
b. Dendritic cells
c. Mast cells
d. Macrophages
e. Neutrophils

6. Hematopoietic stem cells are distributed between both primary and secondary organized lymphoid tissues; thus facilitating their rapid recognition and expansion in response to invading microbes?
a. True
b. False

7. Which of the following white blood cells plays a major house-keeping role in the body (i.e. eliminates old and dying cells)?
a. Lymphocytes
b. Dendritic cells
c. Mast Cells
d. Macrophages
e. Neutrophils

8. Natural killer (NK) cells, which often can often be microscopically visualized as large granular lymphocytes, are considered to be important in controlling bacterial infections on mucosal surfaces?
a. True
b. False

9. Where in the body are lymphocytes and/or their precursors produced?
a. Spleen
b. Bone Marrow
c. Thymus
d. Lymph node
e. All of the above

10. Where in the body do B lymphocytes develop their antigen receptors and mature?
a. Spleen
b. Bone Marrow
c. Thymus
d. Lymph node
e. All of the above

11. Where in the body do T lymphocytes develop their antigen receptors and mature?
a. Spleen
b. Bone Marrow
c. Thymus
d. Lymph node
e. All of the above

12. Mature lymphocytes routinely move between the blood and organized lymphoid tissue of a healthy individual.
a. True
b. False

13. Neutrophils and eosinophils routinely move between the blood, organized lymphoid tissue and non-lymphoid tissue in a healthy individual.
a. True
b. False

14. The innate and adaptive immune systems differ in which of the following.
a. Response time
b. Specificity
c. Memory
d. All of the above
e. Only a and b are correct

15. Following a tissue insult, the neutrophil is one of the first cells recruited into the site from the peripheral blood.
a. True
b. False 16. B and T lymphocytes are produced in the bone marrow. Upon successful generation of antigen-specific receptors, both the T and B cells depart the bone marrow and enter the blood as functional naïve lymphocytes.
a. True
b. False

17. The majority of naïve B lymphocytes that are generated in the bone marrow will undergo apoptosis within a few weeks.
a. True
b. False

18. B lymphocyte receptors (antibody) bind which of the following?
a. Native antigen
b. Processed antigen presented by cell-surface proteins encoded by the major histocompatibility complex (MHC)
c. Degraded peptides produced by the phagolysosome in neutrophils
d. All of the above
e. None of the above

19. T lymphocytes bind which of the following?
a. Native antigen
b. Processed antigen presented by