score 3.2 (2.4,3.9) for sham vs 10.4 (8.6,12.2) for MEN; p=0.0????), with no change in Area 1 (Fig 1B). In association with the overlying cartilage damage there was increased thickness and density of subchondral bone in Area 2 in meniscectomised joints (Fig 1C, 80.1% (74.1,86.1) for sham vs 92.8% (86.4,99.2) for MEN, p = 0.?????). Sclerostin was immunolocalised to osteocytes and their canaliculi in the subchondral plate (Fig 1D) and deeper trabecular bone (not shown) in sham-operated joints. There…
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