Massachusetts, USAb; Department of Biological Engineering and Center for Environmental Health Sciences, Laboratory for Computational Biology & Biophysics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USAc ABSTRACT Herpes simplex virus (HSV) utilizes and subverts host chromatin mechanisms to express its lytic gene products in mammalian cells. The host cell attempts to silence the incoming viral genome by epigenetic mechanisms, but the viral VP16 and ICP0 proteins promote active chromatin…
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