Shake that up on the floor,
Move it, now gimme some more
Twerk that, til you are sore,
Now turn to page 394. f f f f f f dmd me dmd m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m mm m m m m m m m m m m m m mm m mm m m m m m m m m m m m m mm m m m mm m The first antipsychotic drug was discovered by accident and then used for schizophrenia. This was Thorazine, which was soon followed by medications such as Haldol, Prolixin, Navane, Stelazine, Trilafon, and Mellaril. These drugs have become known as "neuroleptics" (meaning, "take the neuron") because, although effective in treating positive symptoms (acute symptoms such as hallucinations, delusions, thought disorder, loose associations, ambivalence, or emotional lability), they can cause cognitive dulling and involuntary movements, among other side effects. These older medications also are not so effective against so-called negative symptoms such as apathy, decreased motivation, and lack of emotional expressiveness.

In 1989, a new class of antipsychotics -- called atypical antipsychotics -- was introduced. At the correct doses, fewer of the neurological side effects -- which often include such symptoms as muscular rigidity, painful spasms, restlessness, or tremors -- are seen.

The first of the new class, Clozaril is the only drug that has been shown to be effective where other antipsychotics have failed. It is not linked with the side