Activity of Gastrointestinal Smooth Muscle: Worksheet

Please Ensure That You Have Completed The Calculations In Tables 1-3 Before You Answer The Worksheet Questions

Table 1. The effects of phentolamine and atropine on the contractile response to nerve stimulation (20 Hz) in the isolated rabbit ileum

| |Contraction amplitude |Contraction amplitude with the |Effect of nerve stimulation on the contraction amplitude |
| |pre-nerve stimulation |maximum response to nerve | |
| | |stimulation |PLEASE SHOW YOUR CALCULATIONS |
| |Maximum – Minimum |Maximum – Minimum |Express the effect of nerve stimulation as % change (from |
| |= mV |= mV |pre-nerve stimulation to maximum response to nerve |
| | | |stimulation): |
| | | | |
| | | |= % |
|with phentolamine |Maximum – Minimum |Maximum – Minimum |Express the effect of nerve stimulation as % change (from |
| |= mV |= mV |pre-nerve stimulation to maximum response to nerve |
| | | |stimulation): |
| | | |= % |
| |Maximum – Minimum |Maximum – Minimum |Express the effect of nerve stimulation as % change (from |
|with atropine |= mV |= mV |pre-nerve stimulation to maximum response to nerve |
| | | |stimulation): |
| | | |= % |

Table 2. The effects of phentolamine and atropine on the contractile response to noradrenaline in the isolated rabbit ileum

| | |Contraction amplitude with the | |
| |Contraction amplitude |maximum response to |Effect of noradrenaline on the contraction amplitude |
| |pre-noradrenaline |noradrenaline | |
| | | |PLEASE SHOW YOUR CALCULATIONS |
| |Maximum – Minimum |Maximum – Minimum |Express the effect of noradrenaline as % change (from |
| |= mV |= mV |pre-noradrenaline to maximum response to noradrenaline): |
| | | |= % |
|with phentolamine |Maximum – Minimum |Maximum – Minimum |Express the effect of noradrenaline as % change (from |
| |=