HEMATOPOIESIS Lyn is required for normal stem cell factor–induced proliferation and chemotaxis of primary hematopoietic cells Bridget O’Laughlin-Bunner, Nina Radosevic, Marcia L. Taylor, Shivakrupa, Candy DeBerry, Dean D. Metcalfe, Meijuan Zhou, Clifford Lowell, and Diana Linnekin Stem cell factor (SCF) binds to c-Kit and is an important mediator of survival, growth, and function of hematopoietic progenitor cells and mast cells. Lyn and other Src family members are activated by SCF…
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