Torres, Ávila, to John II of Castile and Isabella of Portugal on 22 April 1451.[1] At the time of her birth, she was second in line to throne after her older half-brother Henry. Henry was 26 at that time and married but childless. Her younger brother Alfonso was born two years later on 17 November 1453, lowering her position to third in line.[2] When her father died in 1454, her half-brother ascended to the throne as Henry IV. Isabella and Alfonso were left in Henry's care.[3] She, her mother and her…
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