focusing on mechanism rather than phenotype for obesity. MORTALITY AND MORBIDITY Obesity shortens lifespan by nine years of life for the average person [8]. In adolescence, obesity creates the same risk of premature death as heavy smoking [9]. Diabesity along the entire continuum of metabolic dysfunction is the primary driver of diabetes, cardiovascular disease [10], stroke, dementia [11], cancer [12], and most chronic disease mortality [13]. A recent 40-year prospective study of 4857 Pima Indian…
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