Sharjah American International School

Biology

Done By:

16-02-2010

Outline:
Abstract
a) Down syndrome b) Interesting topic c) Understanding why down syndrome occurs Introduction a) Who discovered Down syndrome b) What is Down syndrome
Body research A. What Causes it and is it inherited?

1-Trisomy 21
2-Mosaic Down syndrome
3-Translocation Down syndrome

B. How Down syndrome affects Kids
1-Physical features
2-Learning

C. Risk factors
1-Advancing maternal age
2- Being carriers of the genetic translocation for Down syndrome
3-Having had one child with Down syndrome

D. Health Issues
1- Health complications
2-Average life expectancy

E. Can Down syndrome be cured?
Risk factors
Some parents have a greater risk of having a baby with Down syndrome. Risk factors include:
Advance maternal age. A woman's chances of giving birth to a child with Down syndrome increase with age because older eggs have a greater risk of improper chromosome division. Scientists do know that women age 35 and older have a significantly higher risk of having a child with the condition.
Frequency of Down syndrome
Per Maternal Age Age (years) | Frequency of Fetuses with Down
Syndrome to Normal Fetuses at 16 weeks of pregnancy | Frequency of Live Births of
Babies with Down Syndrome to Normal Births | 15 - 19 | ---- | 1 / 1250 | 20 - 24 | ---- | 1 / 1400 | 25 - 29 | ---- | 1 / 1100 | 30 - 31 | ---- | 1 / 900 | 32 | ---- | 1 / 750 | 33 | 1 / 420 | 1 / 625 | 34 | 1 / 325 | 1 / 500 | 35 | 1 / 250 | 1 / 350 | 36 | 1 / 200 | 1 / 275 | 37 | 1 / 150 | 1 / 225 | 38 | 1 / 120 | 1 / 175 | 39 | 1 / 100 | 1 / 140 | 40 | 1 / 75 | 1 / 100 | 41 | 1 / 60 | 1 / 85 | 42 | 1 / 45 | 1 / 65 | 43 | 1 / 35 | 1 / 50 | 44 | 1 / 30 | 1 / 40 | 45 and older | 1 / 20 | 1 / 25 |

* Having had one child with Down syndrome. Typically, a woman who has one child with Down syndrome has about a 1 percent chance of having another child with Down syndrome. * Being carriers of the genetic translocation for Down syndrome.