for only 20-25% of disease occurrence. However, among these factors, several are related to sex steroid hormones: sex of the affected individuals [women), early age of menarche and late age of menopause, parity, late age at first pregnancy, and obesity in postmenopausal women. Methods. Theoretical models and laboratory data support hormonal mechanisms of carcinogenesis, particularly as they relate to proliferation of breast ductal epithelium and terminal end bud growth and differentiation in…
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