several structure activity relationships (SAR) studies14-16 have been carried out using the structure of ∆9-ΤΗC, the natural material, as the template. This has resulted in several very potent agonists e.g.,11-hydroxy-∆9-ΤΗC-DMH (dimethylheptyl), HU-210, DMHP SP-1, BRL-4664, , CP-55,940, nabilone etc. In addition, several aminoalkylindoles (AAIs) like WIN-55,212-2 have been identified as agonists and several pyrazole derivatives such as SR-141716A and SR-144528 have been shown to be potent antagonists…
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