migraineurs experience irritability, hunger, craving for food, difficulties with temperature control and somnolence; interestingly, a similar catalogue of symptoms is produced by lesions of the ventromedial nucleus of the hypothalamus in experimental animals.1 Other arguments for the hypothalamic initiation of attacks are the circadian rhythmicity of the onset of migraine attacks2 and the remarkable temporal relation of hormonal fluctuations and the onset of migraine in female patients (in whom migraine…
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