Trisomy 21 According to genetics, the cause of Trisomy 21 is when three copies are made, rather than the usual two copies of genes on chromosome 21. Typically, parents of an individual affected with this genetic disorder are genetically normal. The chances of parents with one child affected with Down syndrome and having a second child with the syndrome as well are at 1% risk, if both parents are determined to have normal karyotypes. In Trisomy 21, there are three genetic variations of Trisomy 21…
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