alteplase (Actvase, tPA), Streptokinase (Retevase) Activate plasminogen; plasminogen generates plasmin (the enzyme that dissolves clots). Used in early MI within 4 – 6 hours: restores blood flow, limit myocardial damage, preserve left ventricular function and prevent death. Contraindications: active internal bleeding, history of hemorrhagic stroke, intracranial problems, surgery within 10 days, uncontrolled HTN. ------------------------------------------------- Side effects: bleeding dysrhythmias…
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